PE 22-28 is a potent TREK-1 inhibitor with an IC50 value of 0.12 nM, demonstrating its efficacy in modulating TREK-1 activity. This 7-amino-acid peptide serves as a core sequence for generating analogs through chemical modifications or amino acid substitutions. PE 22-28 is relevant for research into depression, offering insights into the role of TREK-1 in mood regulation and potential therapeutic interventions.
PE 22-28 is a potent TREK-1 inhibitor with an IC50 value of 0.12 nM, demonstrating its efficacy in modulating TREK-1 activity. This 7-amino-acid peptide serves as a core sequence for generating analogs through chemical modifications or amino acid substitutions. PE 22-28 is relevant for research into depression, offering insights into the role of TREK-1 in mood regulation and potential therapeutic interventions.
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