Pebezertinib (BLU-451) is an orally bioavailable epidermal growth factor receptor (EGFR) inhibitor with demonstrated central nervous system (CNS) penetration. It is specifically designed to target EGFR mutations, including exon 20 insertions, and is being investigated for the treatment of non-small cell lung cancer (NSCLC) harboring these alterations. Pebezertinib represents a promising therapeutic candidate for overcoming resistance in EGFR-driven NSCLC, particularly in cases with CNS involvement.
Pebezertinib (BLU-451) is an orally bioavailable epidermal growth factor receptor (EGFR) inhibitor with demonstrated central nervous system (CNS) penetration. It is specifically designed to target EGFR mutations, including exon 20 insertions, and is being investigated for the treatment of non-small cell lung cancer (NSCLC) harboring these alterations. Pebezertinib represents a promising therapeutic candidate for overcoming resistance in EGFR-driven NSCLC, particularly in cases with CNS involvement.
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
