Penitrem A is an indole diterpene alkaloid that selectively antagonizes large-conductance calcium-activated potassium (BK) channels. This compound exhibits notable antiproliferative and anti-invasive properties across various cancer types. Additionally, Penitrem A enhances the spontaneous release of neurotransmitters such as glutamate, gamma-aminobutyric acid (GABA), and aspartate from cerebrocortical synaptosomes, leading to tremorgenic effects in animal models. Its unique mechanism makes it a valuable tool for studying neuronal signaling and cancer research.
Penitrem A is an indole diterpene alkaloid that selectively antagonizes large-conductance calcium-activated potassium (BK) channels. This compound exhibits notable antiproliferative and anti-invasive properties across various cancer types. Additionally, Penitrem A enhances the spontaneous release of neurotransmitters such as glutamate, gamma-aminobutyric acid (GABA), and aspartate from cerebrocortical synaptosomes, leading to tremorgenic effects in animal models. Its unique mechanism makes it a valuable tool for studying neuronal signaling and cancer research.
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