Perfluoro(2-methyl-3-oxahexanoic) acid is a potent agonist of peroxisome proliferator-activated receptor α (PPARα), exhibiting an EC50 of 2.1 μM for human PPARα. This compound plays a critical role in inducing peroxisome proliferation and elevating proinflammatory mediators, which can lead to impaired intestinal barrier function and disrupted cecal flora balance. Its applications span research into developmental toxicity, hepatotoxicity, and intestinal toxicity, providing valuable insights into these biological processes.
Perfluoro(2-methyl-3-oxahexanoic) acid is a potent agonist of peroxisome proliferator-activated receptor α (PPARα), exhibiting an EC50 of 2.1 μM for human PPARα. This compound plays a critical role in inducing peroxisome proliferation and elevating proinflammatory mediators, which can lead to impaired intestinal barrier function and disrupted cecal flora balance. Its applications span research into developmental toxicity, hepatotoxicity, and intestinal toxicity, providing valuable insights into these biological processes.
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