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Biological Activity
PF-04447943 is a potent, selective brain penetrant PDE9 inhibitor that increased indicators of hippocampal synaptic plasticity and improved cognitive function in a variety of cognition models in both rats and mice.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.29 mL | 126.44 mL | 252.87 mL |
| 0.5 mM | 5.06 mL | 25.29 mL | 50.57 mL |
| 1 mM | 2.53 mL | 12.64 mL | 25.29 mL |
| 5 mM | 0.51 mL | 2.53 mL | 5.06 mL |
*The above data is based on the productmolecular weight 395.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13121 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1082744-20-4 |
| Formula | C20H25N7O2 |
| M. Wt | 395.46 |
| Purity | >98% |
| Synonyms | PF04447943, PF 04447943 |
| SMILES | C[[email protected]@H]1CN(C[[email protected]]1C2=NC(=O)C3=CNN(C3=N2)C4CCOCC4)CC5=NC=CC=N5 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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