PF-04455242 is a selective antagonist of the κ-opioid receptor, exhibiting a high binding affinity with an average Ki value of 3.0 nM in human tissues. This compound is known for its ability to block κ-opioid receptor-mediated analgesia and has demonstrated antidepressant-like effects in preclinical models. Additionally, PF-04455242 is effective in attenuating behavioral responses associated with stress, making it valuable for research into pain modulation and mood disorders.
PF-04455242 is a selective antagonist of the κ-opioid receptor, exhibiting a high binding affinity with an average Ki value of 3.0 nM in human tissues. This compound is known for its ability to block κ-opioid receptor-mediated analgesia and has demonstrated antidepressant-like effects in preclinical models. Additionally, PF-04455242 is effective in attenuating behavioral responses associated with stress, making it valuable for research into pain modulation and mood disorders.
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