PF-04827736 is a selective phosphodiesterase 1 (PDE1) inhibitor, exhibiting IC50 values of 9.1 nM, 38 nM, and 42 nM for PDE1B, PDE1C, and PDE1A, respectively. This compound demonstrates a high degree of selectivity for human PDE1 compared to other members of the PDE superfamily (PDE2-PDE11). PF-04827736 is primarily utilized in research related to cardiovascular disease, providing valuable insights into the role of PDE1 in cardiovascular pathology and potential therapeutic interventions.
PF-04827736 is a selective phosphodiesterase 1 (PDE1) inhibitor, exhibiting IC50 values of 9.1 nM, 38 nM, and 42 nM for PDE1B, PDE1C, and PDE1A, respectively. This compound demonstrates a high degree of selectivity for human PDE1 compared to other members of the PDE superfamily (PDE2-PDE11). PF-04827736 is primarily utilized in research related to cardiovascular disease, providing valuable insights into the role of PDE1 in cardiovascular pathology and potential therapeutic interventions.
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