PF-06807656 is a highly selective inhibitor of the renal outer medullary potassium channel (ROMK or Kir1.1), exhibiting an IC50 of 61 nM against human ROMK in patch-clamp assays. This compound demonstrates significant selectivity for inhibiting rat ROMK and remains effective against N171D pore mutations. PF-06807656 serves as a valuable tool in cardiovascular disease research, enabling the exploration of potassium channel modulation in renal function and related pathophysiological conditions.
PF-06807656 is a highly selective inhibitor of the renal outer medullary potassium channel (ROMK or Kir1.1), exhibiting an IC50 of 61 nM against human ROMK in patch-clamp assays. This compound demonstrates significant selectivity for inhibiting rat ROMK and remains effective against N171D pore mutations. PF-06807656 serves as a valuable tool in cardiovascular disease research, enabling the exploration of potassium channel modulation in renal function and related pathophysiological conditions.
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