PF 4981517

Catalog No.: A12544

CYP3A4 inhibitor

PF 4981517 Chemical Structure

CAS NO. 1390637-82-7

PF 4981517 is a potent and selective inhibitor of CYP3A4 (IC50 values are 0.03, 17 and 70 μM for CYP3A4, CYP3A5 and CYP3A7 respectively).

Availability: In stock

Package Price Qty
5 mg
$80.00
10 mg
$140.00
25 mg
$280.00
50 mg
$500.00
10mM * 1mL in DMSO
$132.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

PF 4981517 is a potent and selective inhibitor of CYP3A4 (IC50 values are 0.03, 17 and 70 μM for CYP3A4, CYP3A5 and CYP3A7 respectively).
Targets
CYP3A4
30 nM
In vitro DMSO 91 mg/mL (199.3 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.9 mL 109.51 mL 219.01 mL
0.5 mM 4.38 mL 21.9 mL 43.8 mL
1 mM 2.19 mL 10.95 mL 21.9 mL
5 mM 0.44 mL 2.19 mL 4.38 mL

*The above data is based on the productmolecular weight 456.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12544
Actions Inhibitor
M. Wt 456.59
Formula C26H32N8
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1390637-82-7
Synonyms PF4981517, PF-4981517
SMILES CC1=CC=C(C=C1)C2=C(C=NN2C)C3=NN(C4=C3C(=NC=N4)N5CC[[email protected]@H](C5)N6CCCCC6)C

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