PF-794 is a selective and potent inhibitor of Traf2- and Nck-interacting kinase (TNIK), exhibiting an IC50 of 39 nM. This ATP-competitive compound specifically targets the TNIK family, leading to a reduction in endogenous p120-catenin phosphorylation in cellular models. PF-794 is utilized in research related to psychiatric disorders, providing a valuable tool for studying the underlying mechanisms of these conditions.
PF-794 is a selective and potent inhibitor of Traf2- and Nck-interacting kinase (TNIK), exhibiting an IC50 of 39 nM. This ATP-competitive compound specifically targets the TNIK family, leading to a reduction in endogenous p120-catenin phosphorylation in cellular models. PF-794 is utilized in research related to psychiatric disorders, providing a valuable tool for studying the underlying mechanisms of these conditions.
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