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(pF)Phe4Nociceptin(1-13)NH2

Catalog No.: A62535
NOP Receptor Agonist
[(pF)Phe4]Nociceptin(1-13)NH2 is a potent and selective agonist for the neuropeptide FF receptor (NOP). With a pKi of 10.68 and a pEC50 of 9.31, it demonstrates significant biological activity, showing over 3000-fold selectivity against δ, κ, and μ opioid receptors. This compound is valuable for research applications aiming to explore nociception, pain modulation, and NOP receptor signaling pathways.
[(pF)Phe4]Nociceptin(1-13)NH2 380620-88-2 NOP Receptor Agonist
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Size Price Stock Qty
1mg
$145.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description[(pF)Phe4]Nociceptin(1-13)NH2 is a potent and selective agonist for the neuropeptide FF receptor (NOP). With a pKi of 10.68 and a pEC50 of 9.31, it demonstrates significant biological activity, showing over 3000-fold selectivity against δ, κ, and μ opioid receptors. This compound is valuable for research applications aiming to explore nociception, pain modulation, and NOP receptor signaling pathways.
Product Information
Catalog NumA62535
FormulaC61H99FN22O15
Molecular Weight1399.58
CAS Number380620-88-2
Sequence shorteningFGG{Phe(4-F)}TGARKSARK-NH2
SMILES[C@H](CC1=CC=C(F)C=C1)(C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(N)=O)=O)CCCNC(=N)N)=O)C)=O)CO)=O)CCCCN)=O)CCCNC(=N)N)=O)C)=O)=O)[C@@H](C)O)=O)NC(CNC(CNC([C@H](CC2=CC=CC=C2)N)=O)=O)=O
Useful Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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GPCR/G Protein > Opioid Receptors