PFK-158

Catalog No.: A14398

PFK-2/FBPase inhibitor

PFK-158

PFK-158 Chemical Structure

CAS NO. 1462249-75-7

PFK-158 is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFK-2/FBPase) isoform 3 (PFKFB3) and derivative of 3-(3-pyridinyl)-1-[4-pyridinyl]-2-propen-1-one (3PO), with potential antineoplastic activity.

Availability: In stock

Package Price Qty
5 mg
$55.00
10 mg
$90.00
25 mg
$190.00
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Biological Activity

PFK-158 is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFK-2/FBPase) isoform 3 (PFKFB3) and derivative of 3-(3-pyridinyl)-1-[4-pyridinyl]-2-propen-1-one (3PO), with potential antineoplastic activity.
In vitro DMSO 14 mg/mL (42.64 mM)
Water <1 mg/mL
Ethanol 4 mg/mL (12.18 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 30.46 mL 152.3 mL 304.61 mL
0.5 mM 6.09 mL 30.46 mL 60.92 mL
1 mM 3.05 mL 15.23 mL 30.46 mL
5 mM 0.61 mL 3.05 mL 6.09 mL

*The above data is based on the productmolecular weight 328.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14398
Actions Inhibitor
CAS No. 1462249-75-7
Formula C18H11F3N2O
M. Wt 328.29
Purity >98%
Synonyms PFK 158, PFK158, ACT-PEK-158
SMILES O=C(C1=CC=NC=C1)/C=C/C2=NC3=CC(C(F)(F)F)=CC=C3C=C2
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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