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Biological Activity
PG 01 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. PG 01 is effective on G970R although with a significant decrease in potency relative to E193K and δF508.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.75 mL | 113.75 mL | 227.51 mL |
| 0.5 mM | 4.55 mL | 22.75 mL | 45.5 mL |
| 1 mM | 2.28 mL | 11.38 mL | 22.75 mL |
| 5 mM | 0.46 mL | 2.28 mL | 4.55 mL |
*The above data is based on the productmolecular weight 439.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18315 |
|---|---|
| Actions | Potentiator |
| CAS No. | 853138-65-5 |
| Formula | C28H29N3O2 |
| M. Wt | 439.55 |
| Purity | >98% |
| Synonyms | PG01, PG-01 |
| SMILES | O=C(C(C2=CC=CC=C2)N(C)C(CC3=CNC4=C3C=CC=C4)=O)NC1=CC=C(C(C)C)C=C1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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