PHCCC(4Me) is a dual-action modulator targeting mGluR2 and mGluR3, functioning as a negative allosteric modulator (NAM) and a positive allosteric modulator (PAM), respectively. This compound exhibits a half maximal inhibitory concentration (IC50) of 1.5 μM for mGluR2 and an effective concentration (EC50) of 8.9 μM for mGluR3. Its unique pharmacological profile makes PHCCC(4Me) valuable for research applications in neuropharmacology, particularly in the study of glutamate receptor functions and potential therapeutic strategies for neurological disorders.
PHCCC(4Me) is a dual-action modulator targeting mGluR2 and mGluR3, functioning as a negative allosteric modulator (NAM) and a positive allosteric modulator (PAM), respectively. This compound exhibits a half maximal inhibitory concentration (IC50) of 1.5 μM for mGluR2 and an effective concentration (EC50) of 8.9 μM for mGluR3. Its unique pharmacological profile makes PHCCC(4Me) valuable for research applications in neuropharmacology, particularly in the study of glutamate receptor functions and potential therapeutic strategies for neurological disorders.
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