Fig. 1 · Structure
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PHCCC(4Me)
mGluR2 NAM/mGluR3 PAM
PHCCC(4Me) is a dual-action modulator targeting mGluR2 and mGluR3, functioning as a negative allosteric modulator (NAM) and a positive allosteric modulator (PAM), respectively. This compound exhibits a half maximal inhibitory concentration (IC50) of 1.5 μM for mGluR2 and an effective concentration (EC50) of 8.9 μM for mGluR3. Its unique pharmacological profile makes PHCCC(4Me) valuable for research applications in neuropharmacology, particularly in the study of glutamate receptor functions and potential therapeutic strategies for neurological disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1259532-01-8 |
| Applications | mGluR2 NAM/mGluR3 PAM |
| Formula | C18H16N2O3 |
| Molecular Weight | 308.33 |
| Synonyms | THCCC |
| SMILES | O=C(NC1=CC=C(C=C1)C)C23CC2/C(C4=C(C=CC=C4)O3)=N\O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.