Phosphodiesterase-IN-2 is a selective inhibitor of phosphodiesterase 10A (PDE10A), demonstrating an IC50 value of 11.9 nM. This compound enhances the stability of liver microsomes while demonstrating reduced permeability across the blood-brain barrier. Additionally, Phosphodiesterase-IN-2 exhibits favorable pharmacokinetic properties and has been shown to mitigate isoprenaline-induced cardiac hypertrophy in murine models, making it a valuable tool for cardiac research and drug development.
Phosphodiesterase-IN-2 is a selective inhibitor of phosphodiesterase 10A (PDE10A), demonstrating an IC50 value of 11.9 nM. This compound enhances the stability of liver microsomes while demonstrating reduced permeability across the blood-brain barrier. Additionally, Phosphodiesterase-IN-2 exhibits favorable pharmacokinetic properties and has been shown to mitigate isoprenaline-induced cardiac hypertrophy in murine models, making it a valuable tool for cardiac research and drug development.
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