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Phrixotoxin-1

Catalog No.: A68081
Potassium Channel Inhibitor
Phrixotoxin-1 is a selective peptide inhibitor targeting the Kv4 potassium channel. Derived from the venom of the theraphosid spider Phrixotrichus auratus, it exhibits potent biological activity in the modulation of potassium ion flow. This reagent is valuable for research applications involving neuronal excitability and cardiac function, providing insight into the roles of Kv4 channels in various physiological and pathological processes.
Phrixotoxin-1 221872-97-5 Potassium Channel Inhibitor
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPhrixotoxin-1 is a selective peptide inhibitor targeting the Kv4 potassium channel. Derived from the venom of the theraphosid spider Phrixotrichus auratus, it exhibits potent biological activity in the modulation of potassium ion flow. This reagent is valuable for research applications involving neuronal excitability and cardiac function, providing insight into the roles of Kv4 channels in various physiological and pathological processes.
Product Information
Catalog NumA68081
FormulaC156H240N44O37S7
Molecular Weight3548.30
CAS Number221872-97-5
SequenceTyr-Cys-Gln-Lys-Trp-Met-Trp-Thr-Cys-Asp-Ser-Ala-Arg-Lys-Cys-Cys-Glu-Gly-Leu-Val-Cys-Arg-Leu-Trp-Cys-Lys-Lys-Ile-Ile-NH2 (Disulfide bridge: Cys2-Cys16; Cys9-Cys21; Cys15-Cys25)
Sequence shorteningYCQKWMWTCDSARKCCEGLVCRLWCKKII-NH2 (Disulfide bridge: Cys2-Cys16; Cys9-Cys21; Cys15-Cys25)
SMILESC([C@H](NC([C@@H](NC([C@H](CC=1C=2C(NC1)=CC=CC2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC3=CC=C(O)C=C3)N)=O)CS)=O)CCC(N)=O)=O)CCCCN)=O)=O)CCSC)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC=4C=5C(NC4)=CC=CC5)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]([C@H](CC)C)C(N)=O)=O)[C@H](CC)C)=O)CCCCN)=O)CCCCN)=O)CS)=O)=O)CC(C)C)=O)CCCNC(=N)N)=O)CS)=O)[C@@H](C)C)=O)CC(C)C)=O)=O)CCC(O)=O)=O)CS)=O)CS)=O)CCCCN)=O)CCCNC(=N)N)=O)C)=O)CO)=O)CC(O)=O)=O)CS)=O)[C@@H](C)O)=O)C=6C=7C(NC6)=CC=CC7
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Membrane Transporters-Ion Channels > Potassium Channels