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PI3K/Akt/mTOR
MELK

MELK

Catalog No.

Product Name

Application

Product Information

Product Citation

A12675

MELK-IN-1

MELK inhibitor

MELK-IN-1 is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK) with an IC50 and a Ki of 3 nM and 0.39 nM, respectively.

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A12851

OTSSP167

MELK inhibitor

OTSSP167 is a highly potent MELK (maternal embryonic leucine zipper kinase) inhibitor with IC50 of 0.41 nM.

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- Yubao Wang ,etc. Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival. Proc Natl Acad Sci USA. 2016 Aug 30; 113(35): 9810?€?9815.
A21542

JNJ-47117096 hydrochloride

MELK inhibitor

JNJ-47117096 hydrochloride is potent and selective MELK inhibitor, with an IC50 of 23 nM, also effectively inhibits Flt3, with an IC50 of 18 nM.

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A21751

MELK-8a hydrochloride

MELK inhibitor

MELK-8a hydrochloride is a novel maternal embryonic leucine zipper kinase (MELK) inhibitor with an IC50 of 2 nM.

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A22184

OTSSP167 hydrochloride

MELK inhibitor

OTSSP167 (hydrochloride) is a highly potent MELK inhibitor with IC50 value of 0.41 nM.

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