Pioglitazone-d4 is a deuterium-labeled derivative of Pioglitazone, a selective agonist of the peroxisome proliferator-activated receptor gamma (PPARγ). This compound demonstrates high affinity for the PPARγ ligand-binding domain, with EC50 values of 0.93 μM for human and 0.99 μM for mouse PPARγ. Pioglitazone-d4 is utilized in metabolic research to study insulin sensitivity, adipogenesis, and the mechanisms underlying type 2 diabetes mellitus.
Pioglitazone-d4 is a deuterium-labeled derivative of Pioglitazone, a selective agonist of the peroxisome proliferator-activated receptor gamma (PPARγ). This compound demonstrates high affinity for the PPARγ ligand-binding domain, with EC50 values of 0.93 μM for human and 0.99 μM for mouse PPARγ. Pioglitazone-d4 is utilized in metabolic research to study insulin sensitivity, adipogenesis, and the mechanisms underlying type 2 diabetes mellitus.
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