PIT (2,2'-Pyridylisatogen tosylate) is a selective non-competitive antagonist of the P2Y1 receptor, exhibiting an IC50 value of 0.14 μM for human P2Y1 receptors. It effectively inhibits P2Y1 receptor signaling without interfering with nucleotide binding, demonstrating irreversible antagonism of ATP responses at metabotropic purinoceptors within certain smooth muscle tissues. PIT is valuable for investigating conditions such as chronic bronchitis and asthma, facilitating research into the role of purinergic signaling in these respiratory disorders.
PIT (2,2'-Pyridylisatogen tosylate) is a selective non-competitive antagonist of the P2Y1 receptor, exhibiting an IC50 value of 0.14 μM for human P2Y1 receptors. It effectively inhibits P2Y1 receptor signaling without interfering with nucleotide binding, demonstrating irreversible antagonism of ATP responses at metabotropic purinoceptors within certain smooth muscle tissues. PIT is valuable for investigating conditions such as chronic bronchitis and asthma, facilitating research into the role of purinergic signaling in these respiratory disorders.
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