Pitavastatin is a potent HMG-CoA reductase inhibitor that effectively reduces cholesterol synthesis from acetic acid, demonstrating an IC50 of 5.8 nM in HepG2 cells. This compound functions as a potent inducer of low-density lipoprotein-cholesterol (LDL-C) receptors in hepatocytes. Additionally, Pitavastatin exhibits a broad range of biological activities, including anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective, and reno-protective effects, making it valuable for research in cardiovascular health and metabolic disorders.
Pitavastatin is a potent HMG-CoA reductase inhibitor that effectively reduces cholesterol synthesis from acetic acid, demonstrating an IC50 of 5.8 nM in HepG2 cells. This compound functions as a potent inducer of low-density lipoprotein-cholesterol (LDL-C) receptors in hepatocytes. Additionally, Pitavastatin exhibits a broad range of biological activities, including anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective, and reno-protective effects, making it valuable for research in cardiovascular health and metabolic disorders.
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