PKR Inhibitor

Catalog No.: A13538

PKR Inhibitor

PKR Inhibitor

PKR Inhibitor Chemical Structure

CAS NO. 608512-97-6

PKR Inhibitor is an oxindole/imidazole derivative that binds the ATP-binding site of PKR and blocks autophosphorylation with an IC50 value of 186-210 nM.3 PKR Inhibitor protects human neuroblastoma cells against cell damage triggered by tunicamycin-mediated endoplasmic reticulum stress.

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10 mg
$80.00
25 mg
$180.00
50 mg
$300.00
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Biological Activity

PKR Inhibitor is an oxindole/imidazole derivative that binds the ATP-binding site of PKR and blocks autophosphorylation with an IC50 value of 186-210 nM.3 PKR Inhibitor protects human neuroblastoma cells against cell damage triggered by tunicamycin-mediated endoplasmic reticulum stress.
In vitro DMSO 13 mg/mL (48.45 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 37.27 mL 186.36 mL 372.72 mL
0.5 mM 7.45 mL 37.27 mL 74.54 mL
1 mM 3.73 mL 18.64 mL 37.27 mL
5 mM 0.75 mL 3.73 mL 7.45 mL

*The above data is based on the productmolecular weight 268.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13538
Actions Inhibitor
CAS No. 608512-97-6
Formula C13H8N4OS
M. Wt 268.3
Solubility DMSO
Purity >98%
Synonyms C16, GW 506033X
SMILES C1=CC2=C(C\3=C1NC(=O)/C3=C\C4=CN=CN4)SC=N2
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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