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PLK1-IN-16

Name: PLK1-IN-16
Brand: Adooq Bioscience
SKU: A32944
Availability: OutOfStock

Cat. No. A32944 CAS 3068378-51-5

PLK1 Inhibitor

PLK1-IN-16 is a potent and selective inhibitor of polo-like kinase 1 (PLK1) with an IC50 value of 0.25 nM. This compound is primarily utilized in cancer research due to its ability to induce G2 phase cell cycle arrest and promote apoptosis, displaying significant antiproliferative activity against various tumor cell lines. Additionally, PLK1-IN-16 has been shown to exhibit stability under simulated gastric acid conditions and presents manageable CYP 450 inhibition. Its applications extend to the study of triple-negative breast cancer (TNBC), breast cancer, and leukemia.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3068378-51-5
Applications	PLK1 Inhibitor
Formula	C₂₆H₃₄N₆O₄S
Molecular Weight	526.65
SMILES	O=S(N1C2=CC(OC)=C(NC3=NC=C4C(N(C5CCCC5)[C@H](CC)C(N4C)=O)=N3)C=C2CC1)(C6CC6)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.