PLX7904

Catalog No.: A15855

Raf inhibitor

PLX7904

PLX7904 Chemical Structure

CAS NO. 1393465-84-3

PLX7904 is a potent and selective paradox-breaker RAF inhibitor. It is able to efficiently inhibit activation of ERK1/2 in mutant BRAF melanoma cells but does not hyperactivate ERK1/2 in mutant RAS-expressing cells.

Availability: In stock

Package Price Qty
5 mg
$150.00
10 mg
$250.00
25 mg
$550.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

PLX7904 is a potent and selective paradox-breaker RAF inhibitor. It is able to efficiently inhibit activation of ERK1/2 in mutant BRAF melanoma cells but does not hyperactivate ERK1/2 in mutant RAS-expressing cells.
Targets
Raf
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.51 mL 97.56 mL 195.11 mL
0.5 mM 3.9 mL 19.51 mL 39.02 mL
1 mM 1.95 mL 9.76 mL 19.51 mL
5 mM 0.39 mL 1.95 mL 3.9 mL

*The above data is based on the productmolecular weight 512.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A15855
Actions Inhibitor
M. Wt 512.53
Formula C24H22F2N6O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1393465-84-3
Synonyms PB04
SMILES O=C(C1=CNC2=NC=C(C3=CN=C(C4CC4)N=C3)C=C21)C5=C(F)C=CC(NS(=O)(N(CC)C)=O)=C5F

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