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Catalog No.: A16946

C5a receptor antagonist


PMX-205 Chemical Structure

CAS NO. 514814-49-4

PMX-205 is a cyclic hexapeptide that acts as a potent antagonist of C5a receptor (C5aR; IC50 = 31 nM).

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Biological Activity

PMX-205 is a cyclic hexapeptide that acts as a potent antagonist of C5a receptor (C5aR; IC50 = 31 nM).
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 11.92 mL 59.59 mL 119.18 mL
0.5 mM 2.38 mL 11.92 mL 23.84 mL
1 mM 1.19 mL 5.96 mL 11.92 mL
5 mM 0.24 mL 1.19 mL 2.38 mL

*The above data is based on the productmolecular weight 839.05. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16946
Actions Antagonist
CAS No. 514814-49-4
Formula C45H62N10O6
M. Wt 839.05
Purity >98%
Synonyms PMX205, PMX 205
SMILES O=C([C@]([H])(CC1=CNC2=C1C=CC=C2)NC([C@@H](CC3CCCCC3)NC([C@]4(N5CCC4)[H])=O)=O)N[C@@H](CCCNC(N)=N)C(NCCC[C@@]([H])(C5=O)NC(CCC6=CC=CC=C6)=O)=O

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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