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PNZ5 is a potent and isoxazole-based pan-BET inhibitor with high selectivity and potency similar to the well-established (+)-JQ1, with a KD of 5.43 nM for BRD4(1).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 31.41 mL | 157.05 mL | 314.1 mL |
| 0.5 mM | 6.28 mL | 31.41 mL | 62.82 mL |
| 1 mM | 3.14 mL | 15.7 mL | 31.41 mL |
| 5 mM | 0.63 mL | 3.14 mL | 6.28 mL |
*The above data is based on the productmolecular weight 318.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12764 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1629277-36-6 |
| Formula | C20H18N2O2 |
| M. Wt | 318.37 |
| Purity | >98% |
| Synonyms | PNZ-5, PNZ 5 |
| SMILES | CN1C(C2=CC=C(C3=C(C)ON=C3C)C=C2[[email protected]@]1(C4=CC=CC=C4)[H])=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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