Pomalidomide 4'-PEG2-azide is an E3 ligase ligand-linker conjugate that features a Pomalidomide-derived cereblon ligand attached to a PEG2-based linker, facilitating targeted protein degradation through PROTAC technology. This compound contains an azide group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) as well as strain-promoted azide-alkyne cycloaddition (SPAAC) with alkyne-containing molecules. It serves as a valuable tool for researchers studying targeted protein degradation and exploring E3 ligase interactions.
Pomalidomide 4'-PEG2-azide is an E3 ligase ligand-linker conjugate that features a Pomalidomide-derived cereblon ligand attached to a PEG2-based linker, facilitating targeted protein degradation through PROTAC technology. This compound contains an azide group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) as well as strain-promoted azide-alkyne cycloaddition (SPAAC) with alkyne-containing molecules. It serves as a valuable tool for researchers studying targeted protein degradation and exploring E3 ligase interactions.
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