Pomalidomide 4'-PEG3-azide is an E3 ligase ligand-linker conjugate that combines the cereblon ligand derived from Pomalidomide with a polyethylene glycol (PEG) linker. This compound plays a crucial role in the synthesis of iRucaparib-TP3, a potent PARP1 degrader utilizing the PROTAC strategy. Pomalidomide 4'-PEG3-azide serves as a versatile click chemistry reagent, featuring an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-modified compounds.
Pomalidomide 4'-PEG3-azide is an E3 ligase ligand-linker conjugate that combines the cereblon ligand derived from Pomalidomide with a polyethylene glycol (PEG) linker. This compound plays a crucial role in the synthesis of iRucaparib-TP3, a potent PARP1 degrader utilizing the PROTAC strategy. Pomalidomide 4'-PEG3-azide serves as a versatile click chemistry reagent, featuring an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-modified compounds.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
