Pomalidomide-5-C7-NH2

Catalog No.: A80177
E3 Ligase Ligand-Linker Conjugate
Pomalidomide-5-C7-NH2 serves as an E3 ligase ligand-linker conjugate, utilizing a 5-Aminothalidomide-derived CRBN ligand. This compound is designed to facilitate the development of proteolysis-targeting chimeras (PROTACs), specifically enabling the synthesis of BT-O2C. Its application in protein regulation research underscores its potential in therapeutic strategies targeting E3 ligase-mediated degradation pathways.
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5mg
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50mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPomalidomide-5-C7-NH2 serves as an E3 ligase ligand-linker conjugate, utilizing a 5-Aminothalidomide-derived CRBN ligand. This compound is designed to facilitate the development of proteolysis-targeting chimeras (PROTACs), specifically enabling the synthesis of BT-O2C. Its application in protein regulation research underscores its potential in therapeutic strategies targeting E3 ligase-mediated degradation pathways.
Product Information
Catalog NumA80177
FormulaC20H26N4O4
Molecular Weight386.44
CAS Number2412056-40-5
SMILESNCCCCCCCNC1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2=O)=O)C=C1
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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