Pomalidomide-amido-C4-amido-PEG2-C2-NH-Boc

Catalog No.: A80081
E3 Ligase Ligand-Linker Conjugates
Pomalidomide-amido-C4-amido-PEG2-C2-NH-Boc is an E3 ligase ligand-linker conjugate that features a Pomalidomide-derived cereblon ligand combined with a two-unit polyethylene glycol (PEG) linker. This compound is designed for use in PROTAC (Proteolysis Targeting Chimeras) technology, facilitating targeted protein degradation. Its structure enhances molecular stability and solubility, making it suitable for research applications focused on protein regulation and therapeutic development.
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5mg
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50mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPomalidomide-amido-C4-amido-PEG2-C2-NH-Boc is an E3 ligase ligand-linker conjugate that features a Pomalidomide-derived cereblon ligand combined with a two-unit polyethylene glycol (PEG) linker. This compound is designed for use in PROTAC (Proteolysis Targeting Chimeras) technology, facilitating targeted protein degradation. Its structure enhances molecular stability and solubility, making it suitable for research applications focused on protein regulation and therapeutic development.
Product Information
Catalog NumA80081
FormulaC30H41N5O10
Molecular Weight631.67
CAS Number2435720-04-8
SMILESO=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NC(CCCCC(NCCOCCOCCNC(OC(C)(C)C)=O)=O)=O)=O
SynonymsCereblon Ligand-Linker Conjugates 20; E3 Ligase Ligand-Linker Conjugates 53
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