Pomalidomide-C2-PEG-NHCO-C2-COOH targets cereblon (CRBN) and functions as an E3 ligase ligand-linker conjugate. This compound facilitates the synthesis of proteolysis-targeting chimeras (PROTACs) for the selective degradation of proteins, specifically enabling the development of the ASK1 degrader dASK1. It is valuable for research in targeted protein degradation and E3 ligase modulation.
Pomalidomide-C2-PEG-NHCO-C2-COOH targets cereblon (CRBN) and functions as an E3 ligase ligand-linker conjugate. This compound facilitates the synthesis of proteolysis-targeting chimeras (PROTACs) for the selective degradation of proteins, specifically enabling the development of the ASK1 degrader dASK1. It is valuable for research in targeted protein degradation and E3 ligase modulation.
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