Pomalidomide-PEG2-azide is an E3 ligase ligand-linker conjugate featuring the cereblon ligand derived from Pomalidomide and a 2-unit PEG linker, utilized in proteolysis-targeting chimeras (PROTACs). This compound serves as a click chemistry reagent, containing an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it supports strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds, facilitating targeted protein degradation and expanding research capabilities in chemical biology and therapeutic development.
Pomalidomide-PEG2-azide is an E3 ligase ligand-linker conjugate featuring the cereblon ligand derived from Pomalidomide and a 2-unit PEG linker, utilized in proteolysis-targeting chimeras (PROTACs). This compound serves as a click chemistry reagent, containing an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it supports strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds, facilitating targeted protein degradation and expanding research capabilities in chemical biology and therapeutic development.
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