Poziotinib

Catalog No.: A13044

EGFR inhibitor

Poziotinib Chemical Structure

CAS NO. 1092364-38-9

Poziotinib is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $70.00

Special Price $56.00

10 mg

Regular Price: $100.00

Special Price $80.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Poziotinib is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity.
Targets
HER1 HER2 HER4
3.2 nM5.3 nM23.5 nM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.35 mL 101.76 mL 203.53 mL
0.5 mM 4.07 mL 20.35 mL 40.71 mL
1 mM 2.04 mL 10.18 mL 20.35 mL
5 mM 0.41 mL 2.04 mL 4.07 mL

*The above data is based on the productmolecular weight 491.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13044
Actions Inhibitor
M. Wt 491.34
Formula C23H21Cl2FN4O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1092364-38-9
Synonyms HM781-36B, NOV120101, NOV-120101, NOV 120101
SMILES COC1=C(C=C2C(=C1)N=CN=C2NC3=C(C(=C(C=C3)Cl)Cl)F)OC4CCN(CC4)C(=O)C=C

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