PPACK TFA is a potent and selective irreversible inhibitor of thrombin, demonstrating significant anticoagulant properties. It serves as an alternative to lithium heparin for blood gas and whole blood electrolyte analyses. Additionally, PPACK TFA inhibits plasminogen activator (rt-PA), interfering with its binding to plasma protease inhibitors, and mitigates plasmin-induced alterations in endothelial permeability and morphology in bovine aortic endothelial cell monolayers. This compound is valuable for investigations related to thrombosis and endothelial function.
PPACK TFA is a potent and selective irreversible inhibitor of thrombin, demonstrating significant anticoagulant properties. It serves as an alternative to lithium heparin for blood gas and whole blood electrolyte analyses. Additionally, PPACK TFA inhibits plasminogen activator (rt-PA), interfering with its binding to plasma protease inhibitors, and mitigates plasmin-induced alterations in endothelial permeability and morphology in bovine aortic endothelial cell monolayers. This compound is valuable for investigations related to thrombosis and endothelial function.
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