PPARγ modulator-2 is a reversible modulator of the peroxisome proliferator-activated receptor gamma (PPARγ), targeting its ligand-binding domain with an IC50 of 41 nM. This compound demonstrates significant biological activity by reducing blood glucose levels and enhancing glucose and insulin tolerance. Its efficacy has been validated in db/db mouse models, highlighting its potential applications in diabetes research and metabolic disorders.
PPARγ modulator-2 is a reversible modulator of the peroxisome proliferator-activated receptor gamma (PPARγ), targeting its ligand-binding domain with an IC50 of 41 nM. This compound demonstrates significant biological activity by reducing blood glucose levels and enhancing glucose and insulin tolerance. Its efficacy has been validated in db/db mouse models, highlighting its potential applications in diabetes research and metabolic disorders.
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