Pranlukast hemihydrate is a potent and selective competitive antagonist of peptide leukotrienes, targeting the leukotriene receptor. It effectively inhibits the binding of [3H]LTE4, [3H]LTD4, and [3H]LTC4 to lung membranes, with inhibition constants (Kis) of 0.63±0.11 nM, 0.99±0.19 nM, and 5640±680 nM, respectively. This compound is valuable in research applications related to inflammation and allergic responses, making it a useful tool for studying leukotriene signaling pathways.
Pranlukast hemihydrate is a potent and selective competitive antagonist of peptide leukotrienes, targeting the leukotriene receptor. It effectively inhibits the binding of [3H]LTE4, [3H]LTD4, and [3H]LTC4 to lung membranes, with inhibition constants (Kis) of 0.63±0.11 nM, 0.99±0.19 nM, and 5640±680 nM, respectively. This compound is valuable in research applications related to inflammation and allergic responses, making it a useful tool for studying leukotriene signaling pathways.
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