PRMT5-MTA-IN-5 is an irreversible inhibitor targeting the PRMT5•MTA complex, with an IC50 value of 1.15 nM. This compound effectively inhibits arginine methylation, disrupting ribosomal RNA processing and affecting the expression of proteins associated with the cell cycle. PRMT5-MTA-IN-5 demonstrates potent antiproliferative effects in MTAP-deficient tumor cells, making it a valuable tool for research on MTAP-deficient solid tumors, including liver, breast, and pancreatic cancers.
PRMT5-MTA-IN-5 is an irreversible inhibitor targeting the PRMT5•MTA complex, with an IC50 value of 1.15 nM. This compound effectively inhibits arginine methylation, disrupting ribosomal RNA processing and affecting the expression of proteins associated with the cell cycle. PRMT5-MTA-IN-5 demonstrates potent antiproliferative effects in MTAP-deficient tumor cells, making it a valuable tool for research on MTAP-deficient solid tumors, including liver, breast, and pancreatic cancers.
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