PROTAC AR Degrader-7 is a potent androgen receptor degrader, exhibiting an IC50 value of 3 nM. This bifunctional molecule is designed to engage the androgen receptor through AR ligand-32 while simultaneously recruiting E3 ligase via E3 Ligase Ligand 44 for targeted protein degradation. PROTAC AR Degrader-7 effectively induces ubiquitination and subsequent proteasomal degradation of the androgen receptor, making it a valuable tool for studying androgen receptor signaling and its role in androgen-dependent diseases, particularly prostate cancer.
PROTAC AR Degrader-7 is a potent androgen receptor degrader, exhibiting an IC50 value of 3 nM. This bifunctional molecule is designed to engage the androgen receptor through AR ligand-32 while simultaneously recruiting E3 ligase via E3 Ligase Ligand 44 for targeted protein degradation. PROTAC AR Degrader-7 effectively induces ubiquitination and subsequent proteasomal degradation of the androgen receptor, making it a valuable tool for studying androgen receptor signaling and its role in androgen-dependent diseases, particularly prostate cancer.
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