PROTAC EGFR degrader 3

Catalog No.: A28640
PROTAC EGFR Degrader
PROTAC EGFR Degrader 3 is a potent PROTAC designed to selectively target and degrade mutant EGFR proteins. It demonstrates remarkable cellular activity in H1975 and HCC827 cell lines, effectively facilitating the lysosomal degradation of EGFR mutants. This compound is particularly useful for research applications focused on targeted protein degradation and the study of EGFR-related signaling pathways in cancer.
Grouped product items
Size Price Stock Qty
1mg
$690.00
In stock
5mg
$1,765.00
In stock
10mg
$2,900.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPROTAC EGFR Degrader 3 is a potent PROTAC designed to selectively target and degrade mutant EGFR proteins. It demonstrates remarkable cellular activity in H1975 and HCC827 cell lines, effectively facilitating the lysosomal degradation of EGFR mutants. This compound is particularly useful for research applications focused on targeted protein degradation and the study of EGFR-related signaling pathways in cancer.
Product Information
Catalog NumA28640
FormulaC60H77N13O5S
Molecular Weight1092.40
CAS Number2768472-28-0
SMILESC=CC(N1CCC[C@@H](C1)N2C3=C(N=C2NC4=CC=CC=C4)C=NC(NC5=CC=C(C=C5)N6CCN(CC6)CCCCCCCC(N[C@H](C(N7[C@@H](C[C@H](C7)O)C(N[C@H](C8=CC=C(C=C8)C9=C(N=CS9)C)C)=O)=O)C(C)(C)C)=O)=N3)=O
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