PROTAC EGFR Degrader 8 (T-184) is a proteolysis-targeting chimera (PROTAC) that specifically degrades the epidermal growth factor receptor (EGFR). With a DC50 of 15.56 nM in HCC827 cells, it effectively reduces EGFR levels and demonstrates potent growth inhibition in H1975, PC-9, and HCC827 cell lines, exhibiting IC50 values of 7.72 nM, 121.9 nM, and 14.21 nM, respectively. This compound is valuable for research focusing on cancer biology, particularly non-small cell lung cancer (NSCLC).
PROTAC EGFR Degrader 8 (T-184) is a proteolysis-targeting chimera (PROTAC) that specifically degrades the epidermal growth factor receptor (EGFR). With a DC50 of 15.56 nM in HCC827 cells, it effectively reduces EGFR levels and demonstrates potent growth inhibition in H1975, PC-9, and HCC827 cell lines, exhibiting IC50 values of 7.72 nM, 121.9 nM, and 14.21 nM, respectively. This compound is valuable for research focusing on cancer biology, particularly non-small cell lung cancer (NSCLC).
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