PROTAC ER Degrader-11

Catalog No.: A84624
ER Degrader
PROTAC ER Degrader-11 is a potent PROTAC designed to target estrogen receptor (ER) degradation, with an IC50 of 0.66 nM. This compound plays a critical role in cancer research by modulating ER levels, providing valuable insights into ER-related signaling pathways and therapeutic strategies. Its unique structure includes a Cereblon ligand and a specific linker, making it a valuable tool for exploring targeted protein degradation in cancer biology.
Grouped product items
Size Stock
5mg
10mg
50mg
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPROTAC ER Degrader-11 is a potent PROTAC designed to target estrogen receptor (ER) degradation, with an IC50 of 0.66 nM. This compound plays a critical role in cancer research by modulating ER levels, providing valuable insights into ER-related signaling pathways and therapeutic strategies. Its unique structure includes a Cereblon ligand and a specific linker, making it a valuable tool for exploring targeted protein degradation in cancer biology.
Product Information
Catalog NumA84624
FormulaC43H53N5O4
Molecular Weight703.91
CAS Number2846112-04-5
SMILESCC(C)C[C@@H]1[C@H](C2=CC=C(N3CCC(CC3)CN4CCN(C5=CC=C(C(N([C@@H]6C(NC(CC6)=O)=O)C7)=O)C7=C5)CC4)C=C2)C8=CC=C(O)C=C8CC1
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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