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PROTAC HMGCR Degrader-2

PROTAC HMGCR Degrader

PROTAC HMGCR Degrader-2 selectively targets HMG-CoA reductase (HMGCR) for degradation through the VHL-dependent ubiquitin-proteasome system, exhibiting an IC50 value of 0.25 μM and a DC50 of 0.12 μM in Insig-silenced HepG2 cells. This compound effectively reduces cellular cholesterol levels, making it valuable for research related to hyperlipidemia. Its mechanism of action enables precise modulation of cholesterol biosynthesis pathways, providing insights into lipid metabolism and potential therapeutic interventions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	2715104-46-2
Applications	PROTAC HMGCR Degrader
Formula	C₅₃H₇₉N₅O₁₀S
Molecular Weight	978.29
SMILES	O=C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)[C@H](C(C)(C)C)NC(CCCCCCCCCCNC(O[C@@H]4[C@@]5([H])C(C=C[C@@H]([C@@H]5CC[C@@H](O)C[C@@H](O)CC(O)=O)C)=C[C@@H](C4)C)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.