PROTAC IRAK4 degrader-1

Name: PROTAC IRAK4 degrader-1
Brand: Adooq Bioscience
SKU: A23962
Rating: 5 (288 reviews)

Catalog No.: A23962

PROTAC IRAK4 degrader

PROTAC IRAK4 Degrader-1 is a cereblon-based PROTAC targeting IRAK4, derived from US patent US20190192668A1 (Compound I-210). It induces IRAK4 degradation in OCI-LY-10 cells with <20% at 0.01 μM, >20–50% at 0.1 μM, and >50% at 1 μM.

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PROTAC IRAK4 degrader-1 2360533-90-8 PROTAC IRAK4 degrader

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Grouped product items
Size	Price	Stock
1mg	$495.00	In stock
5mg	$1,150.00	In stock
10mg	$1,780.00	In stock
50mg	$5,680.00	In stock
Bulk Size	Bulk Discount

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Biological Activity

Description	PROTAC IRAK4 Degrader-1 is a cereblon-based PROTAC targeting IRAK4, derived from US patent US20190192668A1 (Compound I-210). It induces IRAK4 degradation in OCI-LY-10 cells with <20% at 0.01 μM, >20–50% at 0.1 μM, and >50% at 1 μM.

Product Information

Catalog Num	A23962
Formula	C44H39F3N12O7
Molecular Weight	904.85
CAS Number	2360533-90-8
SMILES	O=C(C1=CC=C(N2C=C(NC(C3=COC(C4=CC=NC(NCC5CC5)=C4)=N3)=O)C(C(F)(F)F)=N2)C=C1)NCCCN(C=N6)C=C6CNC7=C8C(C(N(C9C(NC(CC9)=O)=O)C8=O)=O)=CC=C7
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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