Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
2-(1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidin-4-yl)acetic acid functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound is instrumental in the synthesis of bifunctional molecules that can effectively harness the ubiquitin-proteasome system for targeted protein degradation. Its structure allows for tailored interactions in various biochemical applications, making it crucial for research in drug discovery and cellular biology. -
PROTAC Linker
tert-Butyl 3-(2-bromoethyl)azetidine-1-carboxylate serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enables the selective degradation of target proteins through the ubiquitin-proteasome system, making it invaluable for research in targeted protein degradation and drug discovery. Its structural properties contribute to effective binding and functionality in the design of novel therapeutic agents. -
PROTAC Linker
4-(Methoxycarbonyl)cyclohexane-1-carboxylic acid serves as a versatile PROTAC linker, facilitating the development of targeted protein degradation compounds. Its unique structural properties enhance the stability and efficacy of PROTACs, enabling precise modulation of protein levels within cellular systems. This reagent is instrumental in research focused on targeted therapies and the study of protein function and regulation. -
PROTAC Linker
1,8-Dibromooctane serves as a PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the stability and efficacy of PROTACs by providing a suitable connection between the targeting moiety and the E3 ligase recruiter. Its versatility makes it valuable in drug discovery and development, particularly in studies aimed at targeted protein degradation. -
PROTAC Linker
1,5-Diiodopentane is a versatile PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). Its unique structure enhances the efficiency of target protein degradation by providing optimal linkages between E3 ligases and the desired substrates. This compound is essential for researchers focusing on targeted protein degradation and the development of innovative therapeutic strategies. -
PROTAC Linker
3-Boc-3-azaspiro[5.5]undecane-9-carbaldehyde is a versatile PROTAC linker utilized in the synthesis of targeted protein degradation compounds. This reagent facilitates the development of PROTAC SOS1 degrader-8, contributing to studies focused on targeted therapy and protein regulation. Its unique structural properties enhance the specificity and effectiveness of protein degradation applications in chemical biology research. -
PROTAC Linker
1,7-Dibromoheptane is a versatile PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in the synthesis of bifunctional molecules, enabling targeted protein degradation for various research applications. Its structural properties allow for optimal interaction with E3 ligases and target proteins, making it an essential tool for advancing studies in targeted therapy and drug development. -
PROTAC Linker
Boc-Azetidine-C2-NH2 is a versatile PROTAC linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). Its unique structure facilitates the formation of covalent bonds essential for targeted protein degradation. This compound is instrumental in advancing drug discovery and optimizing therapeutic modalities by enabling researchers to effectively manipulate protein levels in cellular models. -
PROTAC Linker
1-(Boc)-3-Fluoropiperidine-4-carboxylic acid acts as a key PROTAC linker in the development and synthesis of proteolysis-targeting chimeras (PROTACs). Its structural features enable efficient conjugation to protein ligands and E3 ligase moieties, facilitating targeted protein degradation. This compound is essential for advancing research in targeted therapies and cellular research applications. -
PROTAC Linkers
Boc-NH-O-C1-NHS ester is a versatile alkyl/ether-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). It facilitates the conjugation of target proteins to E3 ligases, enhancing the targeted degradation of proteins of interest. Its application in PROTAC development aids in research focusing on targeted protein modulation and therapeutic interventions in various diseases. -
PROTAC Linker
tert-Butyl 4-(piperidin-4-yl)piperazine-1-carboxylate functions as a PROTAC linker with a critical role in the design and synthesis of PROTAC molecules. This compound facilitates targeted protein degradation by linking degraders to specific protein targets, thereby enhancing the specificity and efficacy of the PROTACs in biological research. It serves as an important tool for studies in drug development and cellular signaling pathways. -
PROTAC Linker
MeOAc-PEG2-acid is a versatile PROTAC linker that facilitates the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances cellular permeability and stability, making it an important component in the development of targeted protein degradation strategies. Its application in chemical research supports investigations into protein regulation and therapeutic interventions. -
PROTAC Linker
Boc-2-methylamino-ethylcarbamate hydrochloride is a PROTAC linker that facilitates the development of proteolysis-targeting chimeras. This compound plays a crucial role in the synthesis of PROTACs, which are designed to selectively degrade target proteins through the ubiquitin-proteasome pathway. Its application in chemical biology research aids in the exploration of targeted protein degradation mechanisms and therapeutic development strategies. -
PROTAC Linker
tert-Butyl 2-oxo-6-azaspiro[3.4]octane-6-carboxylate serves as a crucial PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enhances the specificity and efficacy of targeted protein degradation, making it an invaluable tool in drug discovery and cellular biology research. Its unique spirocyclic structure contributes to improved linker flexibility and optimal binding properties, thereby advancing the study of protein regulation mechanisms. -
PROTAC Linker
8-Boc-2,8-Diazaspiro[4.5]decane hydrochloride is a versatile PROTAC linker utilized in the development of proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of heterobifunctional molecules that engage target proteins for selective degradation through the ubiquitin-proteasome system. Its application is critical in drug discovery, particularly in the search for new therapeutic modalities that can modulate protein levels in a precise manner. -
PROTAC Linker
Undec-10-yn-1-ol serves as a PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the efficiency of targeted protein degradation by linking E3 ligases to specific proteins of interest. Its application is pivotal in advancing research in cellular signaling, protein turnover, and therapeutic development. -
PROTAC Linker
2-Propargyl-(trans)-4-cyclohexanediamine hydrochloride is a PROTAC linker employed in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates targeted degradation of specific proteins by coupling ligand-binding domains of E3 ligases with protein ligands. Its efficacy makes it a valuable tool in the development of innovative therapeutic strategies for various diseases, including cancer. -
PROTAC Linker
Cis-5-Amino-2-Boc-hexahydro-cyclopenta[c]pyrrole serves as a PROTAC linker, playing a pivotal role in the design and synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates targeted degradation of specific proteins, enabling researchers to investigate protein function and unravel complex biological pathways. Its application enhances the development of novel therapeutic strategies in drug discovery and biological research. -
PROTAC Linker
3-Hydroxybicyclo[1.1.1]pentane-1-carboxylic acid serves as a versatile PROTAC linker, facilitating the design and synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound enhances target specificity and binding efficiency in cellular environments, making it valuable for degrading specific proteins. Its applications extend to the field of targeted protein degradation research, aiding the development of therapies for various diseases. -
PROTAC Linker
4-(2-Propynyloxy)benzaldehyde is a versatile PROTAC linker that facilitates the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the stability and efficacy of PROTACs through its unique chemical properties, making it suitable for targeted protein degradation studies in molecular biology and pharmacological research. It serves as an essential building block in the development of novel therapeutic strategies to manipulate protein levels in various cellular contexts. -
PROTAC Linker
tert-Butyl N-(3-hydroxypropyl)-N-methylcarbamate serves as a PROTAC linker, facilitating the development of Proteolysis Targeting Chimeras (PROTACs). This compound plays a crucial role in connecting target proteins to E3 ubiquitin ligases, thereby promoting targeted degradation of specific proteins within a cellular environment. Its use is instrumental in biological research focused on protein homeostasis and targeted therapeutic strategies. -
PROTAC Linkers
7-Bromohept-1-yne is a novel PROTAC linker designed to facilitate targeted protein degradation. It serves as a versatile component in the synthesis of PROTACs, including AK-1690, enabling selective modulation of protein activity. This compound is crucial for advancing research in targeted therapy and proteostasis. -
PROTAC Linker
Boc-C7-COOH is a PROTAC linker utilized in the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective targeting and degradation of proteins by linking an E3 ligase ligand to a target protein ligand. Its application is significant in the development of therapeutic agents aimed at regulated protein degradation and efforts in targeted cancer therapy and other diseases. -
PROTAC Linker
tert-Butyl 6-(hydroxymethyl)-2-azaspiro[3.3]heptane-2-carboxylate serves as a versatile PROTAC linker, facilitating the development of protein degraders through targeted protein interaction. This compound enables the efficient conjugation of E3 ligase ligands to target proteins, enhancing the design and optimization of PROTACs for various therapeutic applications. Its structural features promote tunability in drug development, making it a valuable tool for researchers in chemical biology and drug discovery. -
PROTAC Linker
tert-Butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate hydrochloride serves as a key PROTAC linker, facilitating the construction of proteolysis-targeting chimeras (PROTACs). Its structure aids in enhancing the cell permeability and target engagement of the resultant PROTAC molecules. This compound is instrumental in research applications aimed at targeted protein degradation and the modulation of protein function in various biological contexts. -
PROTAC Linker
Methyl 5-bromopentanoate is a PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). It serves as a key component in the synthesis of these bifunctional molecules, enabling targeted degradation of specific proteins within cellular systems. This compound is valuable in various research applications, including drug discovery and protein dysregulation studies. -
PROTAC Linker
Non-8-yn-1-ol serves as a versatile PROTAC linker, facilitating the synthesis of bifunctional compounds that drive targeted protein degradation. Its structural features enable effective conjugation to both target proteins and E3 ligases, enhancing the specificity and efficacy of PROTACs in various biological studies. This reagent is instrumental in advancing research in cellular regulation, signaling pathways, and therapeutic development. -
PROTAC Linker
4-(4-Hydroxyphenyl)butanoic acid is a versatile PROTAC linker that facilitates the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the selective degradation of target proteins by connecting E3 ligases and bifunctional small molecules. It is widely utilized in research aimed at exploring targeted protein degradation mechanisms and developing novel therapeutic strategies. -
PROTAC Linker
tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate serves as a PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in the targeted degradation of specific proteins by enabling the formation of a covalent bond with proteins of interest. Its utility extends to various research applications in drug discovery and development, particularly for studies involving targeted protein modulation and therapeutic interventions. -
PROTAC Linker
5-Chloropentan-1-ol is a PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in linking the target protein to an E3 ligase, enabling selective protein degradation. 5-Chloropentan-1-ol is instrumental in advancing research in targeted protein modulation and therapeutic development. -
PROTAC Linker
7-Octynylamine (7CI,8CI) is a versatile PROTAC linker known for its utility in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing the recruitment and degradation of specific proteins within cellular systems. Its application in chemical biology enables researchers to explore targeted protein degradation pathways, making it a valuable tool for drug development and therapeutic research. -
PROTAC Linker
11-Aminoundecanoic acid serves as an alkyl chain-based PROTAC linker, essential for the synthesis of proteolysis-targeting chimeras (PROTACs). Its unique structure enhances the stability and efficacy of PROTACs, facilitating targeted protein degradation. This reagent is valuable for researchers investigating novel therapeutic strategies that harness the ubiquitin-proteasome system for selective protein modulation. -
PROTAC Linkers
Mal-PEG4-C2-NH2 TFA is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins with E3 ligases, enhancing targeted protein degradation. It is particularly valuable for researchers developing innovative therapeutics that leverage the ubiquitin-proteasome system for controlled degradation of specific proteins. -
PROTAC Linker
Tetrazine-Ph-NHS ester is a key PROTAC linker utilized in the synthesis of protein-targeting chimeras. This compound features a Tetrazine moiety capable of participating in inverse electron demand Diels-Alder (iEDDA) reactions with trans-cyclooctene (TCO)-modified entities. Its application is vital for the development of targeted protein degradation strategies in chemical biology research, enabling the selective modulation of protein levels within cells. -
PROTAC Linkers
Bis-Tos-PEG6 is a polyethylene glycol (PEG) linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the development of PROTACs by enabling the effective conjugation of E3 ligase recruiters and target proteins, enhancing targeted protein degradation. Its versatile structure allows for increased solubility and improved pharmacokinetic properties, making it an essential tool in chemical biology and drug discovery research. -
PROTAC Linkers
Thiol-C2-PEG2-OH is a polyethylene glycol (PEG)-based linker designed for use in PROTAC synthesis. This compound facilitates the development of PROTACs by enabling the efficient conjugation of target proteins, thereby enhancing the specificity and stability of the resulting compounds. Its application is crucial in studies focused on targeted protein degradation and drug discovery, providing researchers with a valuable tool for investigating proteomic interactions. -
PROTAC Linker
TCO-amine (hydrochloride) is an alkyl chain-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound contains a TCO moiety, enabling it to participate in inverse electron demand Diels-Alder (iEDDA) reactions with tetrazine-containing molecules. TCO-amine (hydrochloride) serves as a crucial tool in targeted protein degradation research, facilitating the development of novel therapeutic agents. -
PROTAC Linker
Acid-PEG5-mono-methyl ester functions as a PEG-based linker for PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the targeted degradation of specific proteins by linking an E3 ligase ligand to a target protein ligand. Its utility in generating PROTACs highlights its significance in drug discovery and development, particularly for addressing challenging therapeutic targets. -
PROTAC Linker
Bpin-Cyclohexene-COOEt is a powerful PROTAC linker that facilitates targeted protein degradation through the formation of bifunctional PROTAC molecules. This reagent enables the efficient synthesis of PROTACs, which harness the ubiquitin-proteasome system to selectively degrade proteins of interest. Its structural characteristics optimize binding affinities and enhance cellular uptake, making it a valuable tool in drug discovery and molecular biology research. -
PROTAC Linker
tert-Butyl 11-aminoundecanoate serves as a versatile PROTAC linker, facilitating the synthesis of a variety of PROTAC molecules. By connecting a ligand for an E3 ubiquitin ligase with a ligand specific for the target protein, it enables the selective degradation of proteins through the ubiquitin-proteasome pathway. This compound is instrumental for researchers aiming to manipulate protein levels and study the dynamics of protein degradation in cellular contexts. -
PROTAC Linkers
m-PEG12-OTs is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). By providing a flexible and hydrophilic interface, m-PEG12-OTs enhances the solubility and stability of PROTAC constructs. This linker is essential in research applications focusing on targeted protein degradation and the development of novel therapeutic strategies. -
PROTAC Linker
Mal-PEG4-propargyl is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. Its application in PROTAC development provides a valuable tool for targeted protein degradation studies in various biological research contexts. -
PROTAC Linker
exo BCN-O-PNB is a versatile alkyl/ether-based PROTAC linker designed for the synthesis of PROTAC molecules. As a click chemistry reagent, it features a BCN group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds. This mechanism facilitates the creation of stable and efficient bifunctional molecules, aiding in targeted protein degradation research applications. -
PROTAC Linker
11-Bromoundecan-1-ol serves as a PROTAC linker, facilitating the development of targeted protein degradation strategies. This compound is pivotal in the synthesis of various PROTACs, including PROTAC GPX4 degrader-4. Its structure enhances the efficiency of degradation pathways, making it a valuable tool for research in targeted therapeutics and protein regulation studies. -
PROTAC Linker
Bromo-PEG2-bromide is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound facilitates the generation of bifunctional molecules that induce targeted protein degradation, thereby modulating protein levels within cellular systems. Its properties make it a valuable tool for researchers investigating selective protein degradation and developing new therapeutic strategies in cancer and other diseases. -
PROTAC Linkers
Nonaethylene glycol monomethyl ether is a polyethylene glycol (PEG) derivative utilized as a linker in protein degradation targeting chimeras (PROTACs). Its structure facilitates the synthesis of novel PROTACs by providing optimal solubility and flexibility, enhancing cellular delivery. This reagent is essential for researchers engaged in studying targeted protein degradation mechanisms and developing therapeutics based on the PROTAC technology. -
PROTAC Linker
tert-Butyl 3-(2-iodoethoxy)propanoate serves as a crucial PROTAC linker, facilitating the creation of targeted protein degradation tools. This compound is instrumental in synthesizing PROTAC FAK degrader 1, contributing to advancements in research focused on protein modulation and degradation pathways. Its unique structural properties enhance the efficacy and specificity of PROTAC assemblies, making it a valuable reagent for chemical biology applications. -
PROTAC Linkers
CH2COOH-PEG3-CH2COOH is a PEG-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enabling the targeted degradation of proteins within cells. It is particularly useful in chemical biology studies aimed at developing novel therapeutic strategies for various diseases through targeted protein degradation. -
PROTAC Linkers
Hydroxy-PEG6-Boc is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the conjugation of target proteins and E3 ligases, enabling selective degradation of proteins through the ubiquitin-proteasome system. This reagent is essential for research applications focused on targeted protein degradation and drug development. -
PROTAC Linker
PEG5-Tos is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates targeted protein degradation by linking a warhead to an E3 ligase, enabling effective modulation of protein levels within cellular systems. PEG5-Tos is an essential tool for researchers investigating protein function and developing novel therapeutic strategies in cancer and other diseases.
