PSB36 is a selective antagonist of the A1 adenosine receptor, exhibiting a Ki of 0.12 nM and Kd of 0.7 nM. This compound has demonstrated efficacy in reducing formalin- and carrageenan-induced edema in murine models, alongside a decrease in pain-related behaviors without causing local paw effects. Furthermore, PSB36 prolongs the action potential duration (APD90) of rat and human atria, enhances frequency-dependent atrial effective refractory period (ERP), raises diastolic thresholds, and mitigates the duration of atrial fibrillation episodes. PSB36 is applicable in research investigating inflammatory pain, hyperalgesia, edema, and atrial fibrillation.
PSB36 is a selective antagonist of the A1 adenosine receptor, exhibiting a Ki of 0.12 nM and Kd of 0.7 nM. This compound has demonstrated efficacy in reducing formalin- and carrageenan-induced edema in murine models, alongside a decrease in pain-related behaviors without causing local paw effects. Furthermore, PSB36 prolongs the action potential duration (APD90) of rat and human atria, enhances frequency-dependent atrial effective refractory period (ERP), raises diastolic thresholds, and mitigates the duration of atrial fibrillation episodes. PSB36 is applicable in research investigating inflammatory pain, hyperalgesia, edema, and atrial fibrillation.
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