PTC124 (Ataluren)
PTC124 also known as Ataluren is CFTR-G542X nonsense allele inhibitor.
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Adooq Products cited in reputable paper
Adooq's PTC124 (Ataluren) has been cited by 3 publications
- Adi Amar-Schwartz, .et al. , Hum Mol Genet, 2023, Jul 20;32(15):2455-2463 PMID: 37145099
- L Kadunc, .et al. , FEBS Lett, 2020, May 13 PMID: 32401336
- Caspi M, .et al. , J Mol Med (Berl), 2016, Apr;94(4):469-82 PMID: 26620677
Biological Activity
| Description | PTC124 also known as Ataluren is CFTR-G542X nonsense allele inhibitor. | ||
|---|---|---|---|
| Targets |
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Product Information
| Catalog Num | A10758 |
|---|---|
| Formula | C15H9FN2O3 |
| Molecular Weight | 284.2 |
| CAS Number | 775304-57-9 |
| SMILES | C1=CC=C(C(=C1)C2=NC(=NO2)C3=CC(=CC=C3)C(=O)O)F |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Solubility
| In vitro (25°C) | DMSO | 55 mg/mL (193.49 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80 | 28 mg/mL | |
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 35.19 mL | 175.93 mL | 351.86 mL |
| 0.5 mM | 7.04 mL | 35.19 mL | 70.37 mL |
| 1 mM | 3.52 mL | 17.59 mL | 35.19 mL |
| 5 mM | 0.7 mL | 3.52 mL | 7.04 mL |
Useful Calculator
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
Please check COA/MSDS for correct molecular weight.
Calculate the dilution required to prepare a stock solution.This equation is commonly abbreviated as: C1V1 = C2V2
