PTC124 (Ataluren)

Catalog No.: A10758

CFTR inhibitor

PTC124 (Ataluren)

PTC124 (Ataluren) Chemical Structure

CAS NO. 775304-57-9

PTC124 also known as Ataluren is CFTR-G542X nonsense allele inhibitor.

Availability: In stock

Package Price Qty
10 mg

Regular Price: $40.00

Special Price $32.00

25 mg

Regular Price: $80.00

Special Price $64.00

50 mg

Regular Price: $120.00

Special Price $96.00

100 mg

Regular Price: $200.00

Special Price $160.00

10mM * 1mL in DMSO

Regular Price: $50.00

Special Price $40.00

Custom Size Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • L Kadunc, .et al. Increased Gene Translation Stringency in Mammalian Cells by Nonsense Suppression at Multiple Permissive Sites With a Single Noncanonical Amino Acid, FEBS Lett, 2020, May 13 PMID: 32401336
  • Caspi M, .et al. A flow cytometry-based reporter assay identifies macrolide antibiotics as nonsense mutation read-through agents, J Mol Med (Berl), 2016, Apr;94(4):469-82 PMID: 26620677

Biological Activity

PTC124 also known as Ataluren is CFTR-G542X nonsense allele inhibitor.
Targets
CFTR (HEK293 cells)
In vitro (25°C) DMSO 55 mg/mL (193.49 mM)
Water Insoluble
Ethanol Insoluble
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 35.19 mL 175.93 mL 351.86 mL
0.5 mM 7.04 mL 35.19 mL 70.37 mL
1 mM 3.52 mL 17.59 mL 35.19 mL
5 mM 0.7 mL 3.52 mL 7.04 mL

*The above data is based on the productmolecular weight 284.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10758
Actions Inhibitor
CAS No. 775304-57-9
Formula C15H9FN2O3
M. Wt 284.2
Purity >98%
Synonyms PTC-124, PTC 124
SMILES C1=CC=C(C(=C1)C2=NC(=NO2)C3=CC(=CC=C3)C(=O)O)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Tags

Product Tags

Other people marked this product with these tags:

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
Keywords:buy PTC124 (Ataluren) | PTC124 (Ataluren) Supplier | purchase | cost | manufacturer | order | distributor | buy 775304-57-9| 775304-57-9 Supplier | purchase 775304-57-9 | 775304-57-9 cost | 775304-57-9 manufacturer | order 775304-57-9 | 775304-57-9 distributor
Rewards