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- Caspi M, .et al. A flow cytometry-based reporter assay identifies macrolide antibiotics as nonsense mutation read-through agents, J Mol Med (Berl), 2016, Apr;94(4):469-82 PMID: 26620677
|Solubility||DMSO>57mg/mL Water<1mg/mL Ethanol<1mg/mL|
|Storage||at -20°C 3 years Powder|
|Synonyms||PTC-124, PTC 124|
|Chemical Name||3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid|
|PTC124 also known as Ataluren is CFTR-G542X nonsense allele inhibitor.|
|Solubility (25°C) *||In vitro||DMSO||57 mg/mL (200.53 mM)|
|Water||<1 mg/mL (<1 mM)|
|Ethanol||<1 mg/mL (<1 mM)|
|In vivo||1% DMSO/30% polyethylene glycol/1% Tween 80||30 mg/mL|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||35.19 mL||175.93 mL||351.86mL|
|0.5 mM||7.04 mL||35.19 mL||70.37 mL|
|1 mM||3.52 mL||17.59 mL||35.19 mL|
|5 mM||0.7 mL||3.52 mL||7.04 mL|
*The above data is based on the productmolecular weight 284.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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