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- L Kadunc, .et al. Increased Gene Translation Stringency in Mammalian Cells by Nonsense Suppression at Multiple Permissive Sites With a Single Noncanonical Amino Acid, FEBS Lett, 2020, May 13 PMID: 32401336
- Caspi M, .et al. A flow cytometry-based reporter assay identifies macrolide antibiotics as nonsense mutation read-through agents, J Mol Med (Berl), 2016, Apr;94(4):469-82 PMID: 26620677
Biological Activity
PTC124 also known as Ataluren is CFTR-G542X nonsense allele inhibitor.
Targets
| CFTR (HEK293 cells) | ||||
| In vitro (25°C) | DMSO | 55 mg/mL (193.49 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80 | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 35.19 mL | 175.93 mL | 351.86 mL |
| 0.5 mM | 7.04 mL | 35.19 mL | 70.37 mL |
| 1 mM | 3.52 mL | 17.59 mL | 35.19 mL |
| 5 mM | 0.7 mL | 3.52 mL | 7.04 mL |
*The above data is based on the productmolecular weight 284.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10758 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 775304-57-9 |
| Formula | C15H9FN2O3 |
| M. Wt | 284.2 |
| Purity | >98% |
| Synonyms | PTC-124, PTC 124 |
| SMILES | C1=CC=C(C(=C1)C2=NC(=NO2)C3=CC(=CC=C3)C(=O)O)F |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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