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PTC124 (Ataluren)

Catalog No.: A10758

CFTR inhibitor

PTC124 (Ataluren)

PTC124 (Ataluren) Chemical Structure

CAS NO. 775304-57-9

PTC124 also known as Ataluren is CFTR-G542X nonsense allele inhibitor.

Availability: In stock

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10 mg
25 mg
50 mg
100 mg
10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • L Kadunc, .et al. Increased Gene Translation Stringency in Mammalian Cells by Nonsense Suppression at Multiple Permissive Sites With a Single Noncanonical Amino Acid, FEBS Lett, 2020, May 13 PMID: 32401336
  • Caspi M, .et al. A flow cytometry-based reporter assay identifies macrolide antibiotics as nonsense mutation read-through agents, J Mol Med (Berl), 2016, Apr;94(4):469-82 PMID: 26620677

Biological Activity

PTC124 also known as Ataluren is CFTR-G542X nonsense allele inhibitor.
CFTR (HEK293 cells)
In vitro (25°C) DMSO 55 mg/mL (193.49 mM)
Water Insoluble
Ethanol Insoluble
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 35.19 mL 175.93 mL 351.86 mL
0.5 mM 7.04 mL 35.19 mL 70.37 mL
1 mM 3.52 mL 17.59 mL 35.19 mL
5 mM 0.7 mL 3.52 mL 7.04 mL

*The above data is based on the productmolecular weight 284.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10758
Actions Inhibitor
CAS No. 775304-57-9
Formula C15H9FN2O3
M. Wt 284.2
Purity >98%
Synonyms PTC-124, PTC 124

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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