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Catalog No.: A11130

Hsp90 Inhibitor


PU-H71 Chemical Structure

CAS NO. 873436-91-0

PU-H71 is a potent Hsp90 inhibitor (IC50 = 50 nM).

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Michael Heider, .et al. The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma, Mol Cell, 2021, Mar 18;81(6):1170-1186 PMID: 33571422
  • Kale S, .et al. HSP90 inhibitor PU-H71 increases radiosensitivity of breast cancer cells metastasized to visceral organs and alters the levels of inflammatory mediators, Naunyn Schmiedebergs Arch Pharmacol, 2019, Sep 14 PMID: 31522240
  • Hiroki Murano, .et al. A purine-type heat shock protein 90 inhibitor promotes the heat shock response in Arabidopsis, Plant Biotechnol Rep, 2017, 11:107-113

Biological Activity

PU-H71 is a potent Hsp90 inhibitor (IC50 = 50 nM).
51 nM
In vitro DMSO 86 mg/mL (167.85 mM)
Water Warmed: 29 mg/mL (56.59 mM)
Ethanol 86 mg/mL (167.85 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.52 mL 97.59 mL 195.17 mL
0.5 mM 3.9 mL 19.52 mL 39.03 mL
1 mM 1.95 mL 9.76 mL 19.52 mL
5 mM 0.39 mL 1.95 mL 3.9 mL

*The above data is based on the productmolecular weight 512.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11130
Actions Inhibitor
CAS No. 873436-91-0
Formula C18H21IN6O2S
M. Wt 512.37
Purity >98%
Synonyms PUH71

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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