PU3 is an Hsp90 inhibitor that targets the conserved ATP/ADP pocket of the Hsp90 protein, competing effectively with geldanamycin and other compounds. This reagent has been shown to induce the degradation of key oncogenic proteins like Her2, subsequently inhibiting breast cancer cell proliferation through mechanisms such as retinoblastoma protein hypophosphorylation, G1 phase cell cycle arrest, and differentiation. PU3 presents a promising avenue for cancer research, particularly in the context of targeted cancer therapies.
PU3 is an Hsp90 inhibitor that targets the conserved ATP/ADP pocket of the Hsp90 protein, competing effectively with geldanamycin and other compounds. This reagent has been shown to induce the degradation of key oncogenic proteins like Her2, subsequently inhibiting breast cancer cell proliferation through mechanisms such as retinoblastoma protein hypophosphorylation, G1 phase cell cycle arrest, and differentiation. PU3 presents a promising avenue for cancer research, particularly in the context of targeted cancer therapies.
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