PW507 is a selective antagonist of the sigma 1 receptor (S1R) with a binding affinity of Ki 7.5 nM for the human variant. With minimal interactions with the sigma 2 receptor (S2R) and hERG channel, PW507 is well-suited for studies requiring brain penetration. This compound is particularly relevant for investigating painful diabetic neuropathy (PDN) and other related conditions.
PW507 is a selective antagonist of the sigma 1 receptor (S1R) with a binding affinity of Ki 7.5 nM for the human variant. With minimal interactions with the sigma 2 receptor (S2R) and hERG channel, PW507 is well-suited for studies requiring brain penetration. This compound is particularly relevant for investigating painful diabetic neuropathy (PDN) and other related conditions.
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