PWZ-029 is a selective inverse agonist targeting the α5 GABAA receptor. It acts as a benzodiazepine site ligand and exhibits a partial agonistic effect on 1- and 3-containing GABAA receptors. In vitro studies demonstrate that PWZ-029 significantly increases retention session latency in mouse fibroblast cells. Furthermore, it has been shown to enhance object recognition in both normal and scopolamine-treated rat models, highlighting its potential applications in cognitive research.
PWZ-029 is a selective inverse agonist targeting the α5 GABAA receptor. It acts as a benzodiazepine site ligand and exhibits a partial agonistic effect on 1- and 3-containing GABAA receptors. In vitro studies demonstrate that PWZ-029 significantly increases retention session latency in mouse fibroblast cells. Furthermore, it has been shown to enhance object recognition in both normal and scopolamine-treated rat models, highlighting its potential applications in cognitive research.
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