PYD-106 is a selective positive allosteric modulator of GluN2C-containing NMDA receptors. This compound enhances the frequency and duration of single-channel currents induced by full agonists while displaying only modest modulation of glutamate and glycine efficacy. Notably, PYD-106 specifically boosts the activity of diheteromeric GluN1/GluN2C receptors without affecting triheteromeric GluN1/GluN2A/GluN2C receptors. Its unique mechanism holds promise for research focused on synaptic transmission and neuropharmacology.
PYD-106 is a selective positive allosteric modulator of GluN2C-containing NMDA receptors. This compound enhances the frequency and duration of single-channel currents induced by full agonists while displaying only modest modulation of glutamate and glycine efficacy. Notably, PYD-106 specifically boosts the activity of diheteromeric GluN1/GluN2C receptors without affecting triheteromeric GluN1/GluN2A/GluN2C receptors. Its unique mechanism holds promise for research focused on synaptic transmission and neuropharmacology.
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